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There are no such cases in New Zealand

PMID: 32537635

Additionally, there is an upsurge in nitric oxide synthesis, activation of nuclear factor-B, an increase in nerve fiber density, elevated levels of serum C-reactive protein, and enhanced production of neuropeptide Y and nerve growth factor

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If you smoke, cessation is strongly advised, as tobacco use weakens the lower esophageal sphincter and worsens reflux

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