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Cells characterized by rapid division (epithelial cells, bone marrow, myeloid cells) appear to have the greatest requirement for cyanocobalamin
maintenance preserves it with less frequent dosing
Intracellular phospholipase A1(iPLA1) is a novel factor involved in coat protein complex I-and Rab6-independent retrograde transport between the endoplasmic reticulum and the golgi complex
It is the same logic as a loading phase followed by a maintenance phase in many research protocols: front-load to establish, then hold with less
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