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Cai, J., Z.Z

Reversible dissociation of gamma-glutamylcysteine synthetase into two subunits

What has already been tried, and what happened

Moreover, Cyp2e1-/- mice showed resistance to the APAP high dose-associated hepatotoxicity, whereas human CYP2E1 transgenic mice were susceptible, suggesting that CYP2E1 is the major P450 enzyme participating in APAP activation (Cheung et al., 2005)

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