glutathione activator prevents high glucose-induced pancreatic fibrosis by suppressing pancreatic stellate cell activation via the ROS/TGFβ/SMAD pathway Targeted inhibition of NOX activation

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These pathways converge to create a state of chronic OS that further exacerbates insulin resistance and -cell dysfunction, and plasma F2-isoprostanes (markers of lipid peroxidation) correlate strongly with HbA1c levels (Tang et al., 2018)

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