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Why GLP-1 Injection Site Reactions Happen GLP-1 medications are given into the subcutaneous fat layer, which means the skin and surrounding tissue interact directly with the medication

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Pregnant or breastfeeding women should avoid AOD-9604 due to lack of safety data in these populations

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J Am Coll Cardiol (2009) 53:50110

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While those numbers are worth noting, theyre comparable to or lower than what is observed with Semaglutide (which saw 7-11% discontinuation across trial arms) and suggest manageable tolerability for most participants

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