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The most commonly reported adverse effects in clinical trials are gastrointestinal in nature, particularly during dose escalation
Symptoms associated with B12 deficiency may include: Persistent fatigue or weakness Memory impairment or confusion Nerve-related issues such as numbness or tingling Mood fluctuations or depression Pale or yellowish skin A B12 deficiency can affect anyone, but older adults are particularly vulnerable
A trend for increased levels of glycine and serine (Fig
The authors thank the Center for Advanced Equipment and Educational Support, Faculty of Agriculture, Kyushu University for the use of the ECL-detection imaging system and the plate-reader
c-Jun N-terminal kinase mediates mouse liver injury through a novel SAB (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src
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