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However, high concentrations of ROS can inhibit glyceraldehyde-3-phosphate dehydrogenase, impeding glycolysis 32 , and this glucose metabolism is crucial for T cell activation and proliferation 33

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10.1016/j.phrs.2016.04.021 92 RivaraM

Recently, GBI-10, a single-stranded DNA-aptamer loaded with dimeric camptothecin prodrug, has been used to specifically target pancreatic ductal adenocarcinoma (PDAC) due to the strong binding affinity against tenascin-C, an overexpressed protein in PDAC [233]

At the same time, this treatment reduces brain tissue loss while multiplying cells