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( 2.3 Long-term and real-world evidence Long-term evidence from selected studies, highlights the sustained clinical benefits of liraglutide and semaglutide ( A number of studies provided compelling evidence that liraglutide significantly improved PASI scores, CRP levels, and VAS pain in obese patients with PsO, regardless of weight loss, highlighting the direct immunomodulatory role of GLP-1Ras ( Finally, in a large scale retrospective cohort study by Sontam et al

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Several data suggested that the latter immune pharmacological activity of DDP4 seems to be independent of its catalytic activity [35] and for this reason unaffected by the use of inhibitors of the enzymatic activity of DPP4 [36]