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For some peptides, metabolites remain detectable days after the parent compound has completely cleared

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Potential use of glutathione for the prevention and treatment of diabetic neuropathy in the streptozotocin-induced diabetic rat

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Here, using wild type mice and human islets, we tested the synergistic activity of such peptide conjugates on glucose-stimulated insulin secretion (GSIS), insulin sensitivity and glucose homeostasis

doi: 10.1056/nejmoa2511774