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ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis
"FHL2, a novel tissue-specific coactivator of the androgen receptor"
* Correspondence: Shun Wang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
For patients dealing with complex chronic illnesses, the body's detoxification pathways are often sluggish or completely overwhelmed by the constant generation of inflammatory cytokines and cellular debris
Saliba, F
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