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The gut-microbiome-metabolism axis seems bidirectional, with GLP-1-producing L-cells reacting to microbial metabolites, especially butyrate and propionate

So ideally, we would lose no lean mass at all when we go on a diet or when we get treated with an incretin

GLP-1 agonist drugs such as Ozempic , Wegovy , Mounjaro and others are members of the fastest growing class of drugs worldwide because of myriad benefits that result from losing weight

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We are transparent that conventional medicine does not classify it as a formal diagnosis