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Perioperative considerations With their superiority in glycaemic control, low incidence of fasting hypoglycaemia, roles in weight management, and established evidence for their cardiovascular benefits, GLP-1 agonists present as highly attractive agents in improving patient outcomes in the perioperative setting, with growing interest for these agents to be continued without perioperative interruption

Additionally, individual patient factors including baseline gastric motility, previous gastrointestinal conditions, concomitant medications, and genetic variations in drug metabolismsignificantly influence susceptibility to nausea

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It also assists with blood sugar control, which helps those with type 2 diabetes

The newly formed reactive electrophilic nitrenium and carbonium ions can act as carcinogens and mutagens due to covalent binding to DNA or to other biomolecules