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however, the transposon insertion is at the far C terminus, so it is unclear if this is a functional knockout

If you are experiencing neuropathy symptoms in the feet or lower legs and are considering vitamin B12 therapy, you can find more detailed information about the treatment, assessment process and suitability here: Our clinic is committed to providing clear guidance, evidence informed care, and a supportive environment for those exploring options for nerve pain and foot discomfort

For patients whose levels fall in the borderline or gray zone, a methylmalonic acid (MMA) test provides greater specificity MMA levels rise when B12 is functionally inadequate at the cellular level, even if serum B12 appears borderline normal

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Kannengiesser K et al

J Jilin Med Univ