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FDA's evaluation concluded that the criteria weighed against placement on the list, citing inadequate physicochemical characterization, immunogenicity concerns from impurities and aggregates, lack of clinical effectiveness data for any approved use, and absence of published human exposure data for the proposed subcutaneous and topical routes

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Replacing air with inert nitrogen removes oxygen from the storage environment

Issues like cost, availability, side effects (such as nausea), and the simple fact that obesity is a complex condition drive the search for other solutions

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