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While macrophages and other immune cells can partially clear these ROS, the excessive ROS burden surpasses the clearance capacity of immune cells, allowing residual ROS to further activate necroptosis through positive feedback mechanisms

On the other hand, NFAT signaling is involved in immune function and other physiological processes, raising questions about potential off-target effects

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Pharmacies and online platforms dispense these injectables casually, often marketed as miracle weight-loss solutions

It's the first oral GLP-1 therapy approved for weight management