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In hepatocytes from mice in which the TKT gene was knocked out there is an accumulation of ribose-5-phosphate as well as the nucleotides, inosine, adenosine, and deoxyadenosine
Although oxidative stress was defined originally as a balance between oxidants and antioxidants systems, an equilibrium among antioxidant strategies is needed to avoid the generation of oxidants and ROS (Mari et al., 2010)
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