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It is necessary for the growth and replication of all body cells and the nervous system's functioning, and deficiency causes pernicious anemia and other forms of megaloblastic anemia and neurologic lesions

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NNMT normally methylates nicotinamide using S-adenosylmethionine (SAM) as a methyl donor, producing 1-methylnicotinamide and S-adenosylhomocysteine

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