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Similarly, metformin is safe and well-tolerated with long-term use
Combined with adequate protein intake (widely recommended at 1.2-1.6g per kg of body weight during GLP-1 protocols) and resistance training, the higher dose ranges may actually preserve lean mass better than lower doses, because the energy deficit is being met predominantly through fat oxidation rather than muscle catabolism
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Semaglutidethe active ingredient in Ozempicis typically prescribed for long-term use
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In infusion studies, the combination of PYY 336 and GLP-1 confers stronger suppression of food intake and hunger sensation compared to monotreatment in healthy and obese subjects 57,58,59
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