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Starting with a lower dose (such as 500mg once or twice daily) and gradually increasing may improve tolerability
Conditions associated with GSH depletion are far and wide: neurodegenerative, pulmonary, immune, cardiovascular, age-related, liver disease and more
Nissen and Lincoff suspect that reluctance will erode over time as more of these types of medications get approved for weight loss, particularly if the SELECT and SURMOUNT-MMO trials result in indications for atherosclerotic CVD
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