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The resulting oxidative stress accelerated neuronal damage and degeneration, ultimately promoting the progression of AD [188]
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Materials and methods Cell culture The K-562 and Lenti-X 293T cells were purchased from the American Type Culture Collection (CCL-243, ATCC) and Clontech (#632180), respectively
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mTOR inhibition with rapamycin (sirolimus) robustly induces autophagy, reducing tau and amyloid- aggregation in AD models as well as mutant huntingtin in HD models
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