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Neuroinflammation plus altered circadian rhythm of histamine release may be a cause of early morning insomnia (sometimes called histamine dumping)

In the peripheral system, GLP-1R mediates the actions of GLP-1 via the incretin axis, in which stimulation of the GLP-1R with GLP-1 primarily triggers insulin release from islet cells in a glucose-dependent manner and inhibits glucagon secretion from islet cells (110)

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H., & Veryser, L

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