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GRK2 prevents the shift of M1 into M2 macrophages by mediating PGE2-EP4-cAMP-CREB signaling in synovial macrophages (136)
The study is large (following almost two million people for an average of 3.7 years) and included over 215,000 people on GLP-1 drugs
GLP-1 (glucagon-like peptide-1) is a hormone naturally produced in your gut that plays a vital role in regulating blood sugar and appetite
2013;36(1): e8
However, this efficacy came with trade-offs
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