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For millions of people who have been curious about GLP-1s but hesitant about injections, this moment feels like science just removed a very sharp needle from the equation

Griffioen et al., 2011

Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial

Quite a bit, actually

These combined actions help support glycemic control and may contribute to weight reduction in appropriate patients under medical supervision

While it isnt medically harmful, the sudden change in appearance can affect self-image and confidence