It often comes down to a few key variables
Some case reports noted concerns over exenatide and semaglutide worsening depressive symptoms, and a larger study suggested a slightly increased risk of suicidal behavior with liraglutide
That said, blood pressure spikes can happen for a range of reasons, including stress, pain, smoking, or interactions with other medications
In clinical trials, tirzepatide 15 mg produced roughly twice the weight loss of semaglutide 1 mg, and the SURMOUNT-5 trial directly compared tirzepatide to semaglutide 2.4 mg for obesity, showing tirzepatide superiority
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Semaglutide was present in the milk of lactating rats, however, due to species-specific differences in lactation physiology, the clinical relevance of these data are not clear (see Data)