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A 2011 in vivo study demonstrated that, in this mouse model, the administration of Pioglitazone induces a proadipogenic antitumor response, with the final result of preventing metastasis and reducing tumor size (Zhang et al., 2017) highlighting the importance of the use of this compound in that specific clinical setting

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Here, we review the advances and controversy for a role of leptin in the pathophysiology of immune responses

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