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Patients filling a prescription for either GLP-1RA or SGLT-2i medication and not having filled a prescription for a glucose-lowering drug (except for metformin) in the previous 365 days were considered new users

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GSH also conjugates electrophilic xenobiotics for elimination and has been linked to activation of the Nrf2/HO-1 cytoprotective pathway

Wang Y, Li Y, Xu Y

In preclinical models the fragment stimulates lipolysis, the breakdown of stored fat, and inhibits lipogenesis, the laying-down of new fat, with the proposed signal running through beta-3-adrenergic receptors on fat cells

No individual participant data were used