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For best results, start with 1/4 dose and work up to the full dose over the course of 4 to 10 days
S., Pistilli, E., Guerron, A
The relevant caution from the paper's own discussion is that FOXO4 has a normal role in DNA-damage repair and Foxo4-knockout mice handle acute damage badly, which is why the authors explicitly ruled out permanent FOXO4 inhibition
10.1016/s0092-8674(00)81225-8 Cell 73 KoH
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