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The table below organizes what the literature actually shows, with the evidence tier stated explicitly (clinical human data, preclinical lab/animal data, or anecdotal/inferred)

Upon the application of SiNPs, the activities of SOD and CAT dramatically showed an almost 100% increment in the shoots of maize plants under As stress (S100As3.2) compared to the As-stressed plants without SiNPs (S0AS3.2)

[ 26, 27 ] Pall proposes a number of nutritional and botanical interventions that may reduce peroxynitrite and cytokine levels

As the next phase of this research, more sophisticated in vivo models, incorporating chronic injury paradigms, long-term follow-ups, and genetic or pharmacological modifications of inflammatory pathways, will be critical to substantiate the translational potential of this approach