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These effects, independent of glucose lowering and weight loss, may contribute to CV benefits but are unlikely to fully explain MACE reductions
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The World Health Organization echoes this urgency, flagging obesity as a driver of type 2 diabetes, heart disease, and certain cancers worldwide [WHO]
Mol Metab (2018) 18:314
Similarly, Ipamorelin stimulates growth hormone release but is not usually flagged in basic screenings
And, in fact, the hormonal and body composition changes that occur during menopause can also increase the risk of developing heart disease
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