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GSH biosynthesis occurs exclusively in the cytosol via a two-step ATP-dependent reaction catalysed sequentially by two enzymes: gamma-glutamylcysteine synthetase (GCL also referred to as gamma-glutamylcysteine ligase, comprising the catalytic GCLC subunit and regulatory GCLM subunit), which catalyses the rate-limiting first step of joining glutamate and cysteine

These observations have made BPC-157 a useful research tool for examining peptide-mediated signal transduction, cytoskeletal organization, extracellular matrix dynamics, and the coordination of complex cellular signaling networks

People who should consider BPC-157 for tendon and ligament injuries are listed below

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Annual Review of Biochemistry , 2003

A peptide that modulates VEGFR2 in a cell culture dish, or heals a rat tendon at 10 mcg/kg IP injection, has not been shown to survive oral delivery in a human at 500 mcg and reach musculoskeletal tissue at any meaningful concentration