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showed that fucoidan could help adult male (68 weeks) C57BL/6 J mice who were depressed: those who were exposed to lipopolysaccharide (LPS) and those who were under chronic restraint stress

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While some interventions ( L-carnitine and guanidinoacetic acid, oxaloacetate, CoQ10selenium combination, NADH and NADH-CoQ10 combination ) showed significant reductions in fatigue, methodological limitations, like small sample sizes and missing data, prevent firm conclusions

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