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Without proper nutrition, the body shifts into conservation mode rather than fat-burning mode

doi:10.1186/s12968-018-0491-6 Sinha S, Eisenhaber B, Jensen LJ, Kalbuaji B, Eisenhaber F

GIP and GLP-1 exert their effects by binding to their specific receptors, the GIP receptor (GIPR) and the GLP-1 receptor (GLP-1R), which belong to the G-protein coupled receptor family

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The upper arm is less commonly used for self-injection due to the difficulty of accessing the correct area unassisted