In animals, SGLT2 inhibitors cause dilatation of the renal pelvis and tubules of the kidney when used during the second and third trimester and additionally a relatively large number of unfavorable human pregnancy outcomes are found in humans
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Enzyme inhibitors block the metabolic activity of one or several P-450 enzymes
Inhibiting GCL, which utilizes glutamate to synthesize glutathione, leads to increased glutamate and mEPSC frequency
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