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20.4% (vs 3.0% placebo) is the treatment-policy estimand intention-to-treat, everyone counted regardless of adherence and is the primary result published in NEJM
(4) USADA
The therapy addresses issues including fatigue, oxidative stress, low immunity, and nutrient depletion caused by aging, stress, and environmental factors
B12 supplementation is appropriate for correcting deficiency and supporting endurance performance, not as a weight-loss intervention
This manifests as: Persistent fatigue and weakness Breathlessness, particularly on exertion Palpitations or rapid heartbeat Pale or jaundiced (yellowish) skin Glossitis (sore, red tongue) Neurological and psychiatric symptoms can be particularly concerning and may become irreversible if deficiency remains untreated for extended periods
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