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For AOD-9604 specifically, the disulfide bond is also susceptible to oxidation at warmer temperatures if any oxygen is present

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8 Although folate deficiency may also produce a megaloblastic anemia, it is less common in the United States because of required folate fortification of enriched grain and cereal products

That is precisely why it belongs in the research peptide category, not the approved-drug category

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Int J Diabetes Dev Ctries