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From professional periodontal debridement and specific probiotic strains to natural bioactive compounds and strategic dietary choices, these approaches collectively target the oral-gut axis to restore microbial eubiosis, reinforce barrier integrity, and quell systemic inflammation, thereby offering a holistic framework for combating the wide-ranging impacts of periodontal disease

In addition, suppressed miRNA expression of CYP2E1, GSTpi, and TNF- along with enhanced mitochondrial bioenergetics were suggested to be responsible for the protective effect

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