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The PLC enzymes contain an SH2 domain that allows them to interact with phosphotyrosine residues present on receptors with intrinsic tyrosine kinase activity or with receptor-associated tyrosine kinases
These drugs are particularly valuable for patients with obesity-related conditions like metabolic syndrome, prediabetes, or as recently approved, obstructive sleep apnea (OSA) the FDA approved tirzepatide in OSA because weight loss led to significant improvement in apnea-hypopnea index and symptom resolutionfda.govfda.gov
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This is clinically significant because metabolic dysfunction-associated steatotic liver disease (MASLD) previously known as non-alcoholic fatty liver disease (NAFLD) is estimated to affect approximately 2530% of adults in the UK (British Liver Trust), and can progress to cirrhosis and liver failure if untreated
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Some patients report hair thinning during rapid weight loss phases, which is not unique to tirzepatide but rather associated with significant caloric restriction and rapid body composition changes
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