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doi: 10.1007/s12028-015-0119-8 55 FujimuraS.ShimakageH.TaniokaH.YoshidaM.Suzuki-KusabaM.HisaH.et al
Novel studies found that GLP-1RAs such as liraglutide, semaglutide and exendin-4 reduces -synuclein aggregation respectively in MPTP (a mitochondrial complex I inhibitor) and 6-OHDA induced PD mice models as well as rat model of -synucleinopathy
The study was performed in accordance with the Helsinki Declaration and approved by the ethics committee of Musashino Red Cross Hospital
Unlike its cousin GHK-Cu, which occurs naturally in human plasma, AHK-Cu is entirely synthetic
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Notably, in Arabidopsis thaliana the mutation of arGST tt19 completely eliminates production of epicatechin 34 an unexpected outcome in the frame of the ligandin model as the cytosolic availability of cyanidin ( 8-AH + ), the precursor molecule of epicatechin ( 19 ), should be unaffected by mutating a transport protein
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