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placebo) Adverse events were consistent with those observed in other clinical trials for other incretins, the most common among participants treated with retatrutide (9 mg and 12 mg, respectively) being nausea (38.1% and 43.2% vs 10.7% with placebo), diarrhea (34.7% and 33.1% vs 13.4% with placebo), constipation (21.8% and 25.0% vs 8.7% with placebo), vomiting (20.4% and 20.9% vs 0.0% with placebo), and decreased appetite (19.0% and 18.2% vs 9.4% with placebo)
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Tirzepatide is one option that may be evaluated as part of a structured, physician-guided approach, depending on health history and program goals
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