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95% CI, 0.29-1.24), lung cancer (HR = 0.76

What to Expect in Month 2 Peak nausea: Weeks 6-8 worst for most patients, especially mornings Food aversions: Foods you loved suddenly repulsive (especially meat, coffee) Early satiety: Feel full after 3-4 bites, physical discomfort if you push it Fatigue increases: Combination of medication adjustment and reduced calorie intake Bowel unpredictability: Constipation one day, diarrhea the next Mental fog: Some patients report difficulty concentrating Research from the New England Journal of Medicine on incretin therapies shows this peak-and-resolution pattern is universal across GLP-1 and GIP agonists

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Otros efectos adversos incluyen: Hipoglucemia : Riesgo bajo cuando se usa en monoterapia, pero aumenta significativamente cuando se combina con sulfonilureas o insulina Fatiga y mareos : Reportados en algunos pacientes, posiblemente relacionados con cambios en la ingesta calrica Reacciones en el sitio de inyeccin : Eritema, prurito o induracin leve Aumento de frecuencia cardaca : Incremento promedio de aproximadamente 2-4 latidos por minuto, generalmente sin significancia clnica Efectos adversos graves pero menos frecuentes incluyen pancreatitis aguda (un evento raro observado en ensayos y poscomercializacin), enfermedad de vescula biliar, y posible riesgo de tumores de clulas C tiroideas (observado en estudios con roedores)

They act through multiple mechanisms: Delayed gastric emptying, which slows the release of food from the stomach to the small intestine