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In 2014, Kacem et al
Hyperglycemia increases diacylglycerol (DAG) synthesis, which activates these PKC isoforms in renal tissues, leading to upregulation of profibrotic cytokines such as transforming growth factor-beta (TGF-) and increased production of extracellular-matrix proteins including collagen and fibronectin
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In this context, the emergence of new molecules capable of effectively treating obesity and associated metabolic comorbidities offers a valuable opportunity for broadening therapeutic strategies in PsD patients
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