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It is possible that perturbation of the carnitine shuttle leads to compromised mitochondrial function, which could decrease cellular capacity to handle reactive oxygen species and increase the levels of the inflammatory cytokine, resulting in increased cellular dysfunction and cell death (Mitchell et al., 2018)

Crosstalk between podocytes and endothelial cells leads to endothelial dysfunction under hyperglycemic conditions

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Its studied as a selective NNMT inhibitor in laboratory settings

PMID: 91 ZhouTZhangAKuangGGongXJiangRLinDet al