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Preclinical safety data In mouse studies, 5-amino-1mq was well-tolerated even at doses several times higher than those producing metabolic effects

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For immunoprecipitation, cell lysates were prepared as before and rotated 1 mg proteins with antibody at 4 C overnight, then immunoprecipitated by Protein A/G beads

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3) exhibited enhanced BBB passage when applied to gene delivery in an in vitro model [49]

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