tirzepatide in hfpef pts wiht and obesity, (Mounjaro®) significantly reduces HF hospitalization, diuretic intensification, or CV death by 38% vs placebo in SUMMIT trial https://t.co/8ZHm4gySiL Tirzepatide Benefits in Obesity-Related HFpEF

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MT-IIs MC3R and MC4R activation in hypothalamic energy balance circuits produces significant and dose-dependent food intake reductions

doi: 10.1186/s12944-018-0939-6 137 TangWHWangZKennedyDJWuYBuffaJAAgatisa-BoyleBet al

From those studies, it was suggested that NPY facilitated inflammation, as its concentrations correlated with the number of leukocytes and eosinophils in the bronchoalveolar lavage fluid