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The SH-SY5Y cell line in Parkinsons disease research: a systematic review
185 Besides, other MTHFD2 inhibitors have been reported, including DS18561882 and LY345899 in a substrate-based manner, and treatments based on them decrease cellular NADPH/NADP + ratio, increase cellular ROS levels, and impair tumorigenesis and metastasis
This coordinated activation allows calcium to flow into the neuron, a fundamental process that drives synaptic plasticity, long-term potentiation, learning, and memory formation
PMID: 10373343
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