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Johnson RR, Cranston HJ, Chaverra ME, Dyer WE (1995) Characterization of cDNA clones for differentially expressed genes in embryos of dormant and non-dormant Avenua fatua (L.) caryopses

However, mitochondrial dysfunction can lead to a buildup of ROS due to an imbalance in their production and degradation 4,5 Another major source of ROS is NADPH oxidase (Nox), a membrane-bound enzyme complex that produces superoxide by transferring an electron to oxygen from NADPH

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A PubMed scoping review of high-dose IV vitamin C found over 932 adverse events across 2,801 participants, including kidney damage from oxalate buildup and red blood cell breakdown in G6PD-deficient patients

However, a separate study indicated that the inhibition of PFKFB3 activated HIF-1 and transcriptionally upregulated PD-L1 expression with reduced levels of CD8 and GZMB and shorter survival times in ESCC patients, suggesting that PFKFB3 may act as a protumor-immunity factor [286]