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Users stopping vitamin C serums generally report gradual benefit decline over 2-4 months with antioxidant protection loss occurring quickly (days to weeks), skin brightness fading over 1-2 months returning toward baseline, and collagen-related firmness improvements showing variable persistence with 30-50% benefit retention long-term for consistent users

Front Aging Neurosci 16:1400544

Research indicates its ability to: Stimulate Collagen and Elastin Production: These essential proteins are crucial for skin structure, firmness, and elasticity

Reduced dorsal prefrontal gray matter after chronic ketamine use

More recent clinical work on combined GHRH/GHS secretagogue treatment found measurable increases in serum IGF-1, reinforcing why researchers pair both mechanisms in a single spray formulation (Sigalos et al., Am J Mens Health, 2017)

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