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We found here that agonist trafficking properties, as well as insulin secretion, mirrored -arrestin recruitment propensity, contrasting with some 14,33 (but not all 34 ) previous work suggesting that -arrestins do not impact GLP-1R trafficking 14,34,35 , as well as reports of coupling of GLP-1R to insulin secretion via -arrestin-1 14 (although not -arrestin-2 60 )
As a result, the regulatory environment for compounded GLP-1 medications continues to shift, and patient access pathways may change over time
Balancing the optimism regarding these drugs with grounded strategies that encompass lifestyle, diet, and equitable healthcare access will be the linchpin to ensuring sustainable and widespread positive outcomes
1138), -agatoxin IVA (100 nM, Sigma Aldrich: cat
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