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Severe hyperhomocysteinemia in patients is able to develop neurological and cardiovascular disorders as well as premature death owing to complications [106]
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reported that a single knockout of Hsf2 resulted in reduced testicular volume and mild spermatogenic abnormalities, whereas mice with a double knockout of Hsf1 and Hsf2 were completely infertile (Wang et al., 2004)
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Some of the methods used for the isolation and identification of CSCs include primary extraction 40,41 , fluorescence activation 42 , magnetic activated cell sorting 43,44 , and side population selection 45
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