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10.3390/nu13093013 10 BouranisJ

SGLT2 inhibitors, including empagliflozin, reduce blood glucose and body mass while enhancing hepatic autophagy through the AMPK-TET2 and AMPK/mTOR signaling pathways, thereby attenuating hepatic steatosis

Notably, DHLbut not lanosterolpotently activates liver X receptor alpha (LXR), suggesting that FOXO4 modulates cholesterol metabolism by enhancing DHL-mediated LXR signaling

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